Scientific Perspectives
View AllContinuing Education
Coordinating Evidence-Based Care for Chronic Pain: Multimodal Therapies for a Multidimensional Disease
Charles E. Argoff
2011 Jul 13.
Jeffrey A. Gudin
2012 Mar 21.
David M. Kaufman
2012 Mar 13.
- Acute and Post-Operative Pain
- Cancer-related Pain
- Chronic Noncancer Pain
- Comorbid Conditions
- Fibromyalgia
- Headache
- Interventional Modalites
- Low Back Pain
- Medico-Legal-Ethical Issues
- Neuropathic Pain
- Nonopioid Pharmacotherapy
- Nonpharmacologic Treatment
- Opioid Pharmacotherapy
- Osteoarthritis
- Palliative Care
- Risk Management
- Scientific Perspectives
- Special Patient Populations
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Section Editor
Charles E. Argoff, MD
User Activity
Charles E. Argoff, MD
Features
Continuing Education Activities
Professor of Neurology
Albany Medical College
Director, Comprehensive Pain Center
Albany Medical Center
Albany, New York
Dennis D. Dykstra, MD, PhD
User Activity
Dennis D. Dykstra, MD, PhD
Associate Professor
Chairman
Department of Physical Medicine and Rehabilitation
University of Minnesota
Minneapolis, Minnesota
View AllPublications
Biologic Drugs for Analgesia: Redefining the Opportunity
Pathophysiology of medication overuse headache: Insights and hypotheses from preclinical studies.
An update on the pathophysiology of complex regional pain syndrome.
The genetics of pain: implications for evaluation and treatment of spinal disease.
Translational Pain Research: Achievements and Challenges.
Hughes J, Hatcher JP, Chessell IP.
Curr Pharm Biotechnol. 2011 Apr 5.
Chronic pain...
Curr Pharm Biotechnol. 2011 Apr 5.
Chronic pain...
Pathophysiology of medication overuse headache: Insights and hypotheses from preclinical studies.
Meng ID, Dodick D, Ossipov MH, Porreca F.
Cephalalgia. 2011 Mar 28.
Medication overuse...
Cephalalgia. 2011 Mar 28.
Medication overuse...
An update on the pathophysiology of complex regional pain syndrome.
Bruehl S.
Anesthesiology. 2010;113(3):713-25.
Complex regional pain syndrome (CRPS) is a...
Anesthesiology. 2010;113(3):713-25.
Complex regional pain syndrome (CRPS) is a...
The genetics of pain: implications for evaluation and treatment of spinal disease.
Kim DH, Schwartz, CE.
Spine J. 2010;10(9):827-840.
BACKGROUND CONTEXT: Variability in...
Spine J. 2010;10(9):827-840.
BACKGROUND CONTEXT: Variability in...
Translational Pain Research: Achievements and Challenges.
Mao J.
J Pain. 2009;10(10):1001-11.
The achievements in both preclinical and clinical...
J Pain. 2009;10(10):1001-11.
The achievements in both preclinical and clinical...
Clinician.com Links
Although the subjective nature of pain complicates reproducing and analyzing experiment pain in animal models, preclinical pain research has led to significant progress in clinical pain management.
Over the last few decades, significant achievements in pain research have led to improvements in clinical pain management.
Elucidation of the underpinnings of pain regulation in laboratory animals provides a powerful avenue for research into comparable mechanisms in humans.
Sodium channels are primary determinants of membrane excitability. Interestingly, recent evidence suggests that keratinocytes in the skin express voltage-gated sodium channels, with increased levels observed in such neuropathic pain conditions as complex regional pain syndrome type 1.
Postoperative incisional pain is a unique and common form of acute pain. Despite evidence for reduced morbidity and improved outcomes with effective postoperative pain management, pain remains under-treated after surgery.
The American Pain Society and American Academy of Pain Medicine have recently published guidelines to help clinicians appropriately position and prescribe opioids as a treatment option for chronic noncancer pain.
Chronic pain has been defined as pain that persists longer than 3-6 months, and/or after resolution of the initial injury.
Some experts have suggested that although visual analogue pain ratings are generally reliable for a given individual, comparisons between subjects may be confounded by differences among individuals in past pain experiences.
Previous imaging studies of patients with chronic pain have identified abnormalities in the thalamus, prefrontal cortex, cingulate, and somatosensory cortex, each of which is involved in nociceptive processing.