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Fibromyalgia: Is This a Brain Problem?
Sean C. Mackey, MD, PhD
Pain Genomics
Debra A. Schwinn, MD, Alex Cahana, MD, PhD

Patients may have genetic alleles that affect pain sensitivity or increase the risk for chronic pain development.
ASIPP Guidelines for Interventional Strategies in Chronic Spinal Pain: Epidural Injections
Douglas C. Schottenstein, MD

The American Society of Interventional Pain Physicians (ASIPP) has recently published evidence-based guidelines for interventional strategies in the management of chronic spinal pain. These guidelines evaluate a number of commonly employed...
Advancing Pain Research in Private Practice
Alex Cahana, MD, PhD; Debra A. Schwinn, MD

Clinical trials often fail to represent cohorts observed in general practice, which at times can leave clinicians frustrated with calls for evidence-based medicine.
Cognitive-Behavioral Therapy for Sleep Abnormalities of Chronic Pain Patients
Nicole K. Y. Tang, DPhil

Chronic pain is a biopsychosocial condition that adversely affects multiple domains, including sleep. In fact, most chronic pain patients report fragmented or poor quality sleep. Moreover, studies suggest that pain onset often precedes the...
Physician Enhancement: The Value of Physician Extenders in Pain Medicine
Eric J. Grigsby, MD

Physician extenders in pain medicine generally include physician assistants and nurse practitioners, as well as, at times, clinical nurse specialists, nurse anesthetists, and medical assistants.
The US Food and Drug Administration and Comparative Effectiveness Research
Janet Woodcock, MD

Comparative effectiveness research is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care.
Epidural Injections—Pros and Cons: A Comprehensive Review of Evidence, Epidural Cytokine Therapy, and Complications in the Treatment of Chronic Pain
Salim M. Hayek, MD, PhD

Despite the limited long-term evidence, epidural steroid injections remain the most commonly performed procedure in pain clinics across the United States.
US Food and Drug Administration Concerns Regarding Acetaminophen Toxicity
RADM Sandra Kweder, MD

Acetaminophen is a widely used analgesic found in a number of over-the-counter and prescription products. Despite its benefits for mild to moderate pain, unintentional acetaminophen toxicity represents a growing public health problem.
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Neuromodulation in Special Populations: Examining the Efficacy of Stimulation Versus Intrathecal Pump Therapy
Salim M. Hayek, MD, PhD

Certain patient populations with refractory chronic pain pose particular challenges when considering neuromodulation.

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